The present invention provides human GLP-1 mimetics, including modified immunoglobulins, cleavage products and other specific moieties and variants thereof, as described and / or accomplished herein, and in connection with what is known in the art, also Vectors, host cells, compositions, formulations, devices, transgenic animals, transgenic plants, and methods of making and using the same, for example, in a GLP-L mimetic composition, Crotamiton encoding or complementary nucleic acids.